Adaptive adhesion systems mediate glioma cell invasion in complex environments
نویسندگان
چکیده
منابع مشابه
CD44 mediates human glioma cell adhesion and invasion in vitro.
Human gliomas are characterized by their invasion of normal brain structures irrespective of their grade of malignancy. Factors involved in the control of this invasive behavior are poorly documented. Human gliomas have also been found to express CD44 adhesion molecules. Expression of splice variants of CD44 has been correlated to metastasis in nonglial solid tumors. In this study, 8-microns po...
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High-grade gliomas are the most prevalent and lethal form of primary intracranial tumors. Despite significant progress in surgical and adjuvant therapeutic treatments for gliomas, patient prognosis still remains dismal. The ability of gliomas to invade the normal surrounding brain tissue contributes to their capacity to evade therapeutic interventions, ultimately leading to tumor recurrence and...
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Experimental observations suggest that in the vicinity of the glioma-host interaction zone glioma cells secrete MMPs that dissolve the ECM composition and disturb the balance of the brain tissue [3]. In order to restore the natural balance, healthy brain cells try and produce more ECM components as well as secreting tissue inhibitor of the MMPs (TIMPs) [12]. In this paper we present a mathemati...
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Malignant gliomas have been shown to release glutamate, which kills surrounding brain cells, creating room for tumor expansion. This glutamate release occurs primarily via system xC, a Na+-independent cystine-glutamate exchanger. We show here, in addition, that the released glutamate acts as an essential autocrine/paracrine signal that promotes cell invasion. Specifically, chemotactic invasion ...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2018
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.216382